To provide a medicament containing a peptide derived from Monascus purpureus or Ank-Khak (Monascus purpureus-fermented rice) as an active ingredient, especially having blood pressure increase-inhibiting activity and erythrocyte deformability decrease-inhibiting activity, highly safe, efficacious when oral administered (ingested), and capable of being used as a pharmaceutical, a designated health food, a health food, etc., to provide a method for producing the same, and to provide a processed food of the same.
An angiotensin 2 converting enzyme inhibitor contains a dipeptide Ile-Tyr or its salt, or contains a dipeptide Val-Trp or its salt, or contains a tripeptide Val-Val-Tyr or its salt as an active ingredient. The method for producing the peptide comprises preparing the Ang-Khak by using the Monascus purpureus, obtaining an extract by using the prepared Ang-Khak as a raw material, and treating the obtained extract by column chromatography. The extract or the processed food thereof is obtained by using the Monascus purpureus which produces the peptide and has the erythrocyte deformability decrease-inhibiting activity as a raw material.
INOUE FUMIHIDE
TANABE HATSUO
SEZOKO MASAYASU
KUBA EMI
UNIV RYUKYUS
| JP2004083529A | 2004-03-18 | |||
| JP2001190245A | 2001-07-17 |