Title:
粒子サイズ制御結晶化による鏡像異性体混合物からの鏡像異性体成分の単離方法
Document Type and Number:
Japanese Patent JP5901292
Kind Code:
B2
Abstract:
The present invention discloses a process for isolating enantiomer components from a mixture of enantiomers through particle-size-controlled crystallization, comprising the steps of: (a) forming a solution of a mixture of enantiomers (R) and (S) in a solvent in the absence of any further additives or agents; (b) seeding the solution of step (a) simultaneously or consecutively with seed crystals of enantiomer (R) and with seed crystals of enantiomer (S), wherein the seed crystals of enantiomer (R) differ in size and/or in quantity from the seed crystals of enantiomer (S) to allow separation of the crystals composed of a mixture enriched with enantiomer (R) from the crystals composed of a mixture enriched with enantiomer (S); (c) inducing simultaneous crystallization of enantiomer (R) and enantiomer (S); and (d) isolating crystals composed of a mixture enriched with enantiomer (R) from crystals composed of a mixture enriched with enantiomer (S) through size separation of the crystals, preferably through sieving, melting or sedimentation, in particular through sieving.
Inventors:
Mayard, David
Koller, Guntram
Vacaresco, Yev Genie
Gottburg-Reininger, Sabine
Koller, Guntram
Vacaresco, Yev Genie
Gottburg-Reininger, Sabine
Application Number:
JP2011520493A
Publication Date:
April 06, 2016
Filing Date:
July 28, 2009
Export Citation:
Assignee:
POXEL SAS
International Classes:
C07C29/78; C07B57/00; C07C33/26; C07D251/10
Domestic Patent References:
| JP2005324082A | ||||
| JP379069B1 | ||||
| JP219339A | ||||
| JP2006522753A |
Other References:
Journal of High Resolution Chromatography,1998年,21(7),p.414-416
日本化学会編,標準化学用語辞典,丸善,平成3年3月30日,p.649
日本化学会編,標準化学用語辞典,丸善,平成3年3月30日,p.649
Attorney, Agent or Firm:
Patent business corporation Tsukuni
Hajime Tsukuni
Toshio Miyake
Akio Shibata
Yasuhiro Oguni
Yoko Tanaka
Yoshinori Ikukawa
Hajime Tsukuni
Toshio Miyake
Akio Shibata
Yasuhiro Oguni
Yoko Tanaka
Yoshinori Ikukawa