２−アルキルカルボニルナフト［２，３−ｂ］フラン−４，９−ジオンの関連物質の製造方法、及びその関連物質

Japanese Patent JP6936214

B2

Provided is a method for producing a 2-alkylcarbonylnaphtho[2,3-b]furan-4,9-dione-related substance, which is suitable for the production on an industrial scale. The present invention provides: a method for producing an intermediate for the production of a 2-alkylcarbonyl[2,3-b]furan-4,9-dione, which comprises reacting a 1-butyne derivative in which a ketone or an alcohol is protected with a 2-hydroxy-1,4-naphthoquinone derivative having a leaving group at position-3 in a solvent in the presence of a metal or a metal compound and a base; and a substance relating to the intermediate.

WO/2022/208382	NOVEL DIALKOXYNAPHTHO[2,3-C]FURAN-1(3H)-ONE DERIVATIVES AND PHARMACEUTICAL COMPOSITION FOR PREVENTING OR TREATING RESPIRATORY DISEASE OR SARS-COV-2 INFECTION DISEASE, COMPRISING SAME
JP2016147906	NOVEL Stat3 PATHWAY INHIBITOR AND CANCER STEM CELL INHIBITOR
JPS61238758	INTERMEDIATE FOR MANUFACTURING EPIPODOPHYLLOTOXIN AND RELATED COMPOUNDS, MANUFACTURE AND USE

Kazuhiko Takahashi
Shoji Watanabe
Katsuya Uchiyama
Kento Senami

JP2018507444A

September 15, 2021

March 24, 2017

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Sumitomo Dainippon Pharma Co., Ltd.

C07D307/92; C07D407/04; C07D407/12

JP2012092083A

WO2016157052A1
US20150191478

RAO,M.M. et al,Plant anticancer agents. XII. Isolation and structure elucidation of new cytotoxic quinones from T,Journal of Natural Products,1982年,Vol.45, No.5,pp.600-604

Hidesaku Yamamoto
Natsuki Morishita
Takeshi Komatani
Takatoshi Iida
Daisuke Ishikawa
Kensaku Yamamoto

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