Title:
METHOD FOR DETERMINATION OF ABSOLUTE CONFIGURATION OF CHIRAL COMPOUND
Document Type and Number:
Japanese Patent JP3416776
Kind Code:
B2
Abstract:
PROBLEM TO BE SOLVED: To provide a versatile method for the determination of the absolute configuration of a new chiral compound capable of accurately and easily determining the absolute configuration of chiral compounds having a wide variety of basic groups bonded to the compound.
SOLUTION: The objective method for the determination of the absolute configuration of a chiral compound comprises the preparation of a metal porphyrin having a structure of porphyrin dimer crosslinked with a carbon chain and having a substituent bulkier than ethyl group on at least one of the second carbon atom of one of the porphyrin ring of the dimer structure counted along the outer circumference of the porphyrin ring from the carbon atom crosslinked with the carbon chain, the coordination of the above metal porphyrin with a chiral compound having an asymmetric carbon atom bonded with a basic group coordinatable with the metal of the other porphyrin ring of the metal porphyrin dimer structure or an asymmetric carbon atom positioned adjacent to the carbon atom bonded with the basic group and the determination of the absolute configuration from the sign of Cotton effect determined by circular dichroic spectrophotometric analysis.
Inventors:
Yoshihisa Inoue
Victor Borovkov
Yuha Lin Truoto
Victor Borovkov
Yuha Lin Truoto
Application Number:
JP2000367251A
Publication Date:
June 16, 2003
Filing Date:
December 01, 2000
Export Citation:
Assignee:
Japan Science and Technology Agency
International Classes:
G01N21/19; C07C33/22; C07C211/35; C07D487/22; C07F3/06; (IPC1-7): C07D487/22; C07C33/22; C07C211/35; C07F3/06; G01N21/19
Domestic Patent References:
| JP1029993A |
Other References:
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ＴＥＴＲＡＨＥＤＲＯＮ ＬＥＴＴＥＲＳ，１９９７年，Ｖｏｌ．３８，Ｎｏ．９（１９９７），ｐ１６０３−１６０６
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Attorney, Agent or Firm:
Eiji Saegusa