Title:
METHODS FOR DELIVERING IMPROVED AMINO LIPIDS AND NUCLEIC ACIDS
Document Type and Number:
Japanese Patent JP2016196508
Kind Code:
A
Abstract:
PROBLEM TO BE SOLVED: To provide methods for the delivering improved amino lipids and nucleic acids.SOLUTION: The present invention provides superior compositions and methods for the delivery of therapeutic agents to cells. In particular, these include novel lipids and nucleic acid-lipid particles that provide efficient encapsulation of nucleic acids and efficient delivery of the encapsulated nucleic acid to cells in vivo. The compositions of the present invention are highly potent, thereby allowing effective knock-down of specific target proteins at relatively low doses. In addition, the compositions and methods of the present invention are less toxic and provide a greater therapeutic index compared to compositions and methods previously known in the art.SELECTED DRAWING: Figure 3
Inventors:
HOPE MICHAEL J
SEAN C SEMPLE
CHEN JIANXIN
MADDEN THOMAS D
PIETER R CULLIS
CIUFOLINI MARCO A
BARBARA MUI
SEAN C SEMPLE
CHEN JIANXIN
MADDEN THOMAS D
PIETER R CULLIS
CIUFOLINI MARCO A
BARBARA MUI
Application Number:
JP2016160375A
Publication Date:
November 24, 2016
Filing Date:
August 18, 2016
Export Citation:
Assignee:
TEKMIRA PHARMACEUTICALS CORP
UNIV BRITISH COLUMBIA
UNIV BRITISH COLUMBIA
International Classes:
C07D317/28; A61K9/127; A61K31/708; A61K31/7105; A61K31/713; A61K38/00; A61K39/00; A61K39/002; A61K39/02; A61K39/12; A61K47/22; A61K47/24; A61K47/28; A61K48/00; A61P37/04; C07D319/06
Attorney, Agent or Firm:
Hidesaku Yamamoto
Natsuki Morishita
Natsuki Morishita