Title:
メゾテリンワクチンおよびモデルシステム
Document Type and Number:
Japanese Patent JP2006521090
Kind Code:
A
Abstract:
Mesothelin can be used as an immunotherapeutic target. It induces a cytolytic T cell response. Portions of mesothelin which induce such responses are identified. Vaccines can be either polynucleotide- or polypeptide-based. Carriers for raising a cytolytic T cell response include bacteria and viruses. A mouse model for testing vaccines and other anti-tumor therapeutics and prophylactics comprises a strongly mesothelin-expressing, transformed peritoneal cell line.
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Inventors:
Jeff Elizabeth
Woo Tsi-Chu
Han Chen
Furvan Ralph
Woo Tsi-Chu
Han Chen
Furvan Ralph
Application Number:
JP2005505117A
Publication Date:
September 21, 2006
Filing Date:
July 14, 2003
Export Citation:
Assignee:
THE JOHNS HOPKINS UNIVERSITY
International Classes:
C12N15/09; A61K38/00; A61K39/00; A61P35/00; C07K14/82; C07K16/30; C07K19/00; C12N1/21; C12N5/06
Attorney, Agent or Firm:
Hatsushi Shimizu
Koichi Niimi
Koichi Niimi