Title:
N-ACETYL MANNOSAMMINE AS THERAPEUTIC AGENT
Document Type and Number:
Japanese Patent JP2016196505
Kind Code:
A
Abstract:
PROBLEM TO BE SOLVED: To provide compositions and methods for treating kidney and muscle dysfunction.SOLUTION: The invention relates to use of N-acetyl mannosamine represented by formula I or a derivative thereof [R1 and R3-R5 are H, lower alkanoyl, carboxylate, or lower alkyl; R2 is lower alkyl, lower alkanoyl alkyl, and lower alkyl alkanoyloxy].SELECTED DRAWING: Figure 5A
Inventors:
MARJAN HUIZING
WILLIAM A GAHL
IRINI MANOLI
ENRIKO KLOOTWIJK
WILLIAM A GAHL
IRINI MANOLI
ENRIKO KLOOTWIJK
Application Number:
JP2016159061A
Publication Date:
November 24, 2016
Filing Date:
August 15, 2016
Export Citation:
Assignee:
US GOVERNMENT
International Classes:
A61K31/7008; A61P13/12; A61P21/00; A61P21/04; A61P43/00
Other References:
HUIZING,M. ET AL: "N-acetylmannosamine treatment rescues a mouse model of hereditary inclusion body myopathy", GLYCOBIOLOGY, vol. 16, no. 11, JPN7013000453, 2006, pages 1110 - 1111, XP009108903
NOGUCHI,S. ET AL: "Reduction of UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase activity and sialylation", J BIOL CHEM, vol. 279, no. 12, JPN7013000454, 2004, pages 11402 - 7, XP002504699, DOI: doi:10.1074/jbc.m313171200
HONG,Y. ET AL: "Lec3 Chinese hamster ovary mutants lack UDP-N-acetylglucosamine 2-epimerase activity because of muta", J BIOL CHEM, vol. 278, no. 52, JPN7013000455, 2003, pages 53045 - 54, XP002504700, DOI: doi:10.1074/JBC.M309967200
NEUROLOGY, vol. Vol.60, No.supplement1,, JPN6013005876, 2003, pages 4 - 133
NOGUCHI,S. ET AL: "Reduction of UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase activity and sialylation", J BIOL CHEM, vol. 279, no. 12, JPN7013000454, 2004, pages 11402 - 7, XP002504699, DOI: doi:10.1074/jbc.m313171200
HONG,Y. ET AL: "Lec3 Chinese hamster ovary mutants lack UDP-N-acetylglucosamine 2-epimerase activity because of muta", J BIOL CHEM, vol. 278, no. 52, JPN7013000455, 2003, pages 53045 - 54, XP002504700, DOI: doi:10.1074/JBC.M309967200
NEUROLOGY, vol. Vol.60, No.supplement1,, JPN6013005876, 2003, pages 4 - 133
Attorney, Agent or Firm:
Hatsushi Shimizu
Masao Haruna
Hirotaka Yamaguchi
Toshi Gobe
Ryuichi Inoue
Toshimitsu Sato
Koichi Niimi
Tomohiko Kobayashi
Masato Ozeki
Kazuya Kawamoto
Masao Haruna
Hirotaka Yamaguchi
Toshi Gobe
Ryuichi Inoue
Toshimitsu Sato
Koichi Niimi
Tomohiko Kobayashi
Masato Ozeki
Kazuya Kawamoto