Title:
NOVEL NK3 RECEPTOR AGONIST
Document Type and Number:
Japanese Patent JP2017081917
Kind Code:
A
Abstract:
PROBLEM TO BE SOLVED: To provide a novel neurokinin 3 receptor (NK3 receptor) selective ligand useful as a therapeutic agent of a disease associated with the oversecretion or lack of tachykinins, such as an agent directed to the improvement of sexual dysfunction associated with pain, sex-hormone oversecretion and lack, the ligand being expected to highly actively and highly selectively act, as well as to continuously act in vivo.SOLUTION: Disclosed is a compound represented by formula (I) or a pharmaceutically acceptable salt thereof. Formula (I) X1-A2-A3-X4-X5-Met-NH[ X1 represents a R1-A1 or a dicarboxylic acid residue which is modified directly or through a linker by one or two polyethyleneglycol (PEG) with a molecular weight 500-5,000, or a derivative thereof; R1 represents an H or a particular chemical group; A1 and A2 represent a particular D or L-amino-acid residue; A3 represents a particular L amino acid which is N-methylated; and X4 and X5 represent Gly-Leu or a dipeptide equivalent thereof.]SELECTED DRAWING: None
Inventors:
OISHI SHINYA
FUJII NOBUTAKA
ONO HIROAKI
KUWAI SHINJI
WAKABAYASHI YOSHIHIRO
YAMAMURA TAKASHI
TANAKA TOMOKI
ENDO NATSUMI
FUJII NOBUTAKA
ONO HIROAKI
KUWAI SHINJI
WAKABAYASHI YOSHIHIRO
YAMAMURA TAKASHI
TANAKA TOMOKI
ENDO NATSUMI
Application Number:
JP2016212208A
Publication Date:
May 18, 2017
Filing Date:
October 28, 2016
Export Citation:
Assignee:
UNIV KYOTO
NAT AGRICULTURE & FOOD RES ORGANIZATION
UNIV TOKYO AGRICULTURE & TECHNOLOGY
NAT AGRICULTURE & FOOD RES ORGANIZATION
UNIV TOKYO AGRICULTURE & TECHNOLOGY
International Classes:
C07K7/06; A61K38/00; A61P15/08; A61P25/04; A61P29/00; A61P43/00
Domestic Patent References:
| JP2001502656A | 2001-02-27 | |||
| JPH09512010A | 1997-12-02 |
Foreign References:
| WO2015083816A1 | 2015-06-11 |
Attorney, Agent or Firm:
Takashima Ichi
Kyoko Doi
Mitsunori Kamata
Yaeko Tamura
Junzo Koike
Hirofumi Toma
Atsuko Akai
Tomiya Tozaki
Kyoko Doi
Mitsunori Kamata
Yaeko Tamura
Junzo Koike
Hirofumi Toma
Atsuko Akai
Tomiya Tozaki