Title:
NEW CARBOXYLIC ACID DERIVATIVE HAVING PHOSPHOLIPASE A2 INHIBITING ACTIVITY
Document Type and Number:
Japanese Patent JP3714978
Kind Code:
B2
Abstract:
PURPOSE: To obtain a new compound capable of inhibiting both of an intracellular phospholipase A2 and a secretion type phospholipase A2.
CONSTITUTION: A compound of formula I {A is OH, NH2 or a lower alkylamino; R1 to R12 are each H, methyl, methoxy or OH, with the proviso that they are simultaneously not H; G1 is a single bond or (CH2)xO(CH2)y[(x) and (y) are each O-5]; G2 is a single bond, O, S, CO, SO or SO2; G3 is an alkyl, an alkenyl, an aryl, an arylalkyl, an arylalkenyl, a bicyclo [3. 1. 1.]heptenyl, bicyclo[2. 2. 1]heptyl, bornyl, chromanyl, formula II [R13 and R14 are each H, an alkyl, an aryl, SO2B (B is an aryl or an alkyl) or COD [D is an aryl, an alkoxy or CH2E (E is an aryl or a heterocycle) or G3 forms a heterocyclic group, etc., together with the adjacent N atom]; (p) and (q) are each 0-2; (n) is 1-8}, e.g. 4-{4-[3-(4-carboxyphenoxy)propoxy]- -2-methoxy-3,5,6-tri- methylbenzoyloxy)-2-methoxy-3,5,6-trimethylbenzamide.
Inventors:
Mitsuaki Otani
Toshiyuki Kato
Yozo Hori
Toshiyuki Kato
Yozo Hori
Application Number:
JP23682494A
Publication Date:
November 09, 2005
Filing Date:
September 30, 1994
Export Citation:
Assignee:
Shionogi Pharmaceutical Co., Ltd.
International Classes:
A61K31/235; A61K31/35; A61K31/352; A61K31/40; A61K31/403; A61K31/4035; A61K31/425; A61K31/428; A61K31/44; A61K31/4402; A61K31/445; A61K31/451; A61K31/47; A61K31/495; A61P29/00; A61P43/00; C07C43/225; C07C65/24; C07C69/92; C07C211/52; C07C217/22; C07C233/69; C07C233/92; C07C235/46; C07C235/60; C07D295/08; C07C271/28; C07C311/17; C07C311/48; C07C317/18; C07C323/03; C07C323/12; C07D209/48; C07D211/14; C07D211/70; C07D213/79; C07D215/14; C07D275/04; C07D275/06; C07D295/092; C07D311/22; C07D311/58; (IPC1-7): C07C65/24; A61K31/235; A61K31/35; A61K31/40; A61K31/425; A61K31/44; A61K31/445; A61K31/47; A61K31/495; C07C69/92; C07C211/52; C07C217/22; C07C271/28; C07C317/18; C07C323/12; C07D209/48; C07D211/14; C07D213/79; C07D215/14; C07D275/04; C07D275/06; C07D295/08; C07D311/22; C07D311/58
Domestic Patent References:
| JP57088152A | ||||
| JP55000334A | ||||
| JP48042055B1 | ||||
| JP6171230A | ||||
| JP4159252A | ||||
| JP4159251A | ||||
| JP4117346A |
Foreign References:
| WO1993001157A1 |
Other References:
Cellulose Chemistry and Technology,1985年,19,37-45
Journal of Organic Chemistry,1972年,37(23),3707-3712
Indian Journal of Chemistry,1969年,7(1),56-58
Journal of Organic Chemistry,1972年,37(23),3707-3712
Indian Journal of Chemistry,1969年,7(1),56-58
Attorney, Agent or Firm:
Aoyama Aoi
Kyousei Tamura
Kyousei Tamura