To obtain the subject novel compound that has cathepsin L inhibitory action and is useful for prevention and treatment of osteopathy.
This novel compound is represented by the formula and is prepared by culturing one of imperfect fungi in Hyphomycetes, Periconia sp. Q47630 strain (FERM P-16245), in a culture medium containing L-arabinose, D-xylose or the like as a carbon source and meat essence or peptone as a nitrogen source and sulfate or nitrate of sodium, potassium or the like as metal salts ad additionally a substance generation accelerator at a temp. of 10-30°C and a pH of 4.5-8.5 for about 2-14 days. This novel substance can form a salt with a base as sodium or potassium, a hydrate or a solvate with a solvent as ethanol and can be dosed orally or parenterally.
TANIGUCHI MASATOSHI
NAGAI KOJI
YAMAJI KAYOU
NIIMURA NAMI
