Title:
新規なサポニンアジュバント及びその評価方法
Document Type and Number:
Japanese Patent JP7364587
Kind Code:
B2
Abstract:
The present disclosure is related to the six isomer structures (OBI-821-1990-V1A, OBI-821-1990-V1B, OBI-821-1990-V2A, OBI-821-1990-V2B, OBI-821-1858-A, and OBI-821-1858-B) of isolated OBI-821 adjuvant and the method for evaluating the quality thereof. The method of the present disclosure adopts hydrophilic interaction liquid chromatography (HILIC) and reverse phase high performance liquid chromatography (RP-HPLC) either alone or in tandem and is able to separate the isomers of OBI-821 adjuvant in the consequent chromatography. Accordingly, the quality of OBI-821 adjuvant can be further evaluated.
Inventors:
Chen-da Tony Yu
Lee-Fan Shie
Wei Han Lee
Yoo Chen Lin
Nan Suan Wan
Lee-Fan Shie
Wei Han Lee
Yoo Chen Lin
Nan Suan Wan
Application Number:
JP2020552380A
Publication Date:
October 18, 2023
Filing Date:
March 27, 2019
Export Citation:
Assignee:
Obey Pharma, Incorporated
International Classes:
C07J63/00; B01J20/286; B01J20/287; B01J20/288; G01N30/26; G01N30/32; G01N30/74; G01N30/88
Domestic Patent References:
| JP2019527690A |
Other References:
Carbohydr. Res.,1999年,320,70-81
Anal. Chem.,2003年,75,286-274
Rapid Commun. Mass Spectrom.,2004年,18,2859-2870
J. Pharm. Sci.,1996年,85,22-28
Carbohydr. Res.,1996年,280,1-14
Annals New York Academy of Sciences,1993年,690,392-395
Anal. Chem.,2003年,75,286-274
Rapid Commun. Mass Spectrom.,2004年,18,2859-2870
J. Pharm. Sci.,1996年,85,22-28
Carbohydr. Res.,1996年,280,1-14
Annals New York Academy of Sciences,1993年,690,392-395
Attorney, Agent or Firm:
Yasuhiko Murayama
Shinya Mihiro
Tatsuhiko Abe
Shinya Mihiro
Tatsuhiko Abe