OPTICALLY ACTIVE 2-SUBSTITUTED ALCOHOL, ITS INTERMEDIATE, AND THEIR PRODUCTION

Title:

OPTICALLY ACTIVE 2-SUBSTITUTED ALCOHOL, ITS INTERMEDIATE, AND THEIR PRODUCTION

Document Type and Number:

Japanese Patent JP3735878

Kind Code:

B2

Abstract:

PURPOSE: To provide the new compound useful as a raw material for ferrodielectric liquid crystals, medicines, agricultural chemicals, etc.
CONSTITUTION: This compound is expressed by formula I (R1 is alkyl, aryl, aralkyl, arylpyrimidyl, etc.; R2 is alkyl substituted with two or more halogen atoms), e.g. 2-(4-benzyloxyphenyl)-5-(3,3-difluoro-2-hydroxymethylpropyl) pyrimidine. the compound of formula I is obtained by reducing an optically active 1-(2-substituted acyl)menthopyrazole derivative (with e.g. lithium aluminum halide) in the presence of a basic reagent in a solvent (e.g. THF) at a temperature near to a room temperature. When a bromine atom is contained in the substituent R2 of the compound of formula II, the R2 is hydrolyzed to replace the bromine atom with a hydrogen atom substantially without lowering the optical purity of the compound.

Inventors:

Noriyuki Saito
Honda Hiroshi

Application Number:

JP30890994A

Publication Date:

January 18, 2006

Filing Date:

December 13, 1994

Export Citation:

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Assignee:

Hitachi Chemical Co., Ltd.

International Classes:

C07C33/46; C07D239/26; C07B53/00; C07C29/147; C07C31/34; C07C41/26; C07C43/23; C07D231/56; (IPC1-7): C07C33/46; C07B53/00; C07C29/147; C07C31/34; C07C41/26; C07C43/23; C07D231/56; C07D239/26; //C07M7:00

Domestic Patent References:

JP1075441A
JP1075437A
JP1006230A
JP62234034A

Other References:

Journal of Fluorine Chemistry,1994年,69(1),p.5-6
Tetrahedron Letters,1993年,34(51),p.8305-8308
日本化学会第65春季年会講演予稿集II,1993年,p.81

Attorney, Agent or Firm:

Hajime Tsukuni
Mutsuo Watanabe
Fumio Shinoda

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