OPTICALLY ACTIVE MONOPHOSPHINOCARBOXYLIC ACID DERIVATIVE

Japanese Patent JP3924808

B2

PROBLEM TO BE SOLVED: To obtain the subject new compound derivative which is a specific optically active monophosphinocarboxylic acid derivative useful as a ligand, etc., for a catalyst for asymmetric reaction such as asymmetric allylating reaction, etc., required for producing medicines, agrochemicals or intermediates therefor.
SOLUTION: This new optically active monophosphinocarboxylic acid derivative of formula I [R1 is a 1-6C alkyl or a (substituted) phenyl; R2 is a 1-4C alkyl; R3 and R4 are each H, a 1-4C alkyl or a (substituted) phenyl]. The compound is useful as a ligand for a catalyst for asymmetric reaction such as asymmetric allylating reaction required for producing medicines, agrochemicals or intermediates therefor. The compound is obtained by reacting a substituted acrylic acid derivative represented by formula II with a phosphine compound represented by the formula HP(R1)2 in the presence of a base, providing a racemic monophosphinocarboxylic acid derivative and then carrying out the optical resolution and, as necessary, the separation of diastereoisomers. Furthermore, the compound is reacted with a palladium compound to afford a metallic complex for the asymmetric reactional catalyst, etc.

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JP16889396A

June 06, 2007

June 28, 1996

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Nissan Chemical Industry Co., Ltd.

B01J31/28; C07F9/50; C07B53/00; C07F9/48; C07F15/00; (IPC1-7): C07F9/50; B01J31/28; C07B53/00; C07F9/48; C07F15/00; //C07M7:00

PHOSPHORUS,SULFUR AND SILICON AND THE RELATED ELEMENTS,1989年,42(3-4),p.211-222
CHEMISCHE BERICHTE,1961年,8,p.2244-2251
JOURNAL OF ORGANOMETALLIC CHEMISTRY,1994年,468(1-2),p.99-106

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