Title:
β-セクレターゼ阻害剤としての過フッ素化シクロプロピル縮合1,3-オキサジン-2-アミン化合物、及び使用方法
Document Type and Number:
Japanese Patent JP6374889
Kind Code:
B2
Abstract:
wherein variables A4, A5, A6, A8, each of Ra, Rb, R1, R2, R3 and R7 of Formula I, independently, are defined herein. The invention also provides pharmaceutical compositions comprising the compounds, and uses of the compounds and compositions for treatment of disorders and/or conditions related to A-beta plaque formation and deposition, resulting from the biological activity of BACE. Such BACE mediated disorders include, for example, Alzheimer's Disease, cognitive deficits, cognitive impairments, schizophrenia and other central nervous system conditions. The invention further provides compounds of Formulas II and III, and sub-formula embodiments thereof, intermediates and methods for preparing compounds of the invention.
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Inventors:
Minacci, Anna Elena
Row, Jonathan Dee
Allen, Jennifer Earl
Albert, Amega
Brown, james
Frohn, Michael Jay
Guzman-Perez, Angel
Harrington, Paul Lee
Lopez, Patricia
Boo Bang
Nobuko Nishimura
Chiang, Wen Yuen
Rumfeld, Shannon
Ruzasa, Robert M
Siam, kelvin
Smith, Adrian El
White, ryan
Shwe, Chiufen
Row, Jonathan Dee
Allen, Jennifer Earl
Albert, Amega
Brown, james
Frohn, Michael Jay
Guzman-Perez, Angel
Harrington, Paul Lee
Lopez, Patricia
Boo Bang
Nobuko Nishimura
Chiang, Wen Yuen
Rumfeld, Shannon
Ruzasa, Robert M
Siam, kelvin
Smith, Adrian El
White, ryan
Shwe, Chiufen
Application Number:
JP2015561682A
Publication Date:
August 15, 2018
Filing Date:
March 06, 2014
Export Citation:
Assignee:
Amjien Incorporated
International Classes:
C07D265/12; A61K31/536; A61P25/00; A61P25/16; A61P25/28; A61P43/00; C07D413/12; C07D413/14; C07D417/12; C07D417/14; C07D471/04; C07D491/048
Foreign References:
| WO2011071135A1 | ||||
| WO2013004676A1 | ||||
| WO2011138293A1 | ||||
| WO2014065434A1 |
Attorney, Agent or Firm:
Kawaguchi International Patent Office