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Title:
PHARMACEUTICAL COMPOSITION CONTAINING SODIUM {[3-(2-AMINO-1,2-DIOXOETYL)-2-ETHYL-1-(PHENYLMETHYL)-1H-INDOL-4-YL]OXY}ACETATE AS PHOSPHOLIPASE INHIBITOR
Document Type and Number:
Japanese Patent JP2006096761
Kind Code:
A
Abstract:

To stably keep sodium {[3-(2-amino-1,2-dioxoethyl)-2-ethyl-1-(phenylmethyl)-1H-indol-4-yl]oxy}acetate (referred to as a compound (I)) in an aqueous carrier, and to provide a high-quality, excellent lyophilized formulation containing the compound (I), keeping homogeneous phase, good in reproduction, and causing no disintegration thereof during storage.

The lyophilized pharmaceutical formulation comprises the compound (I), a dissolution agent and a stabilizer. Such a formulation is stable during storage, being readily soluble in an aqueous medium to provide a solution injectible in treating e.g. septicemia.


Inventors:
CONFER WILLIAM LESTER
TAI HIDEAKI
Application Number:
JP2005330964A
Publication Date:
April 13, 2006
Filing Date:
November 16, 2005
Export Citation:
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Assignee:
SHIONOGI & CO
LILLY CO ELI
International Classes:
A61K31/4045; A61K9/00; A61K47/10; A61K9/19; A61K31/404; A61K47/12; A61K47/16; A61K47/24; A61K47/26; A61P29/00; A61P31/04; C07D209/42
Domestic Patent References:
JPH07285933A1995-10-31
JPH02207092A1990-08-16
JPS63159319A1988-07-02
JP3074643B
JPH09504529A1997-05-06
Attorney, Agent or Firm:
Hatsushi Shimizu