Title:
PHARMACEUTICAL COMPOSITIONS COMPRISING BISPECIFIC ANTI-CD3, ANTI-CD19 ANTIBODY CONSTRUCTS FOR TREATMENT OF B-CELL RELATED DISORDERS
Document Type and Number:
Japanese Patent JP2015110628
Kind Code:
A
Abstract:
PROBLEM TO BE SOLVED: To provide a pharmaceutical composition comprising a bispecific single chain antibody construct.SOLUTION: The pharmaceutical composition comprises binding domains specific for human CD3 and human CD19, where corresponding variable heavy chain regions (V) and corresponding variable light chain regions (V) are arranged, from N-terminus to C-terminus, in the order of V(CD19)-V(CD19)-V(CD3)-V(CD3), V(CD3)-V(CD3)-V(CD19)-V(CD19), or V(CD3)-V(CD3)-V(CD19)-V(CD19).
Inventors:
KUFER PETER
LUTTERBUESE RALF
KOHLEISEN BIRGIT
ZEMAN STEVEN
BAEUERLE PATRICK
LUTTERBUESE RALF
KOHLEISEN BIRGIT
ZEMAN STEVEN
BAEUERLE PATRICK
Application Number:
JP2015018323A
Publication Date:
June 18, 2015
Filing Date:
February 02, 2015
Export Citation:
Assignee:
AMGEN RES MUNICH GMBH
International Classes:
A61K39/395; A61K35/74; A61K35/76; A61K38/00; A61K48/00; A61P19/02; A61P29/00; A61P31/04; A61P31/12; A61P33/00; A61P35/00; A61P35/02; A61P37/04; A61P37/06; A61P37/08; C07K16/28
Domestic Patent References:
| JP2002512020A | 2002-04-23 |
Attorney, Agent or Firm:
Hatsushi Shimizu
Masao Haruna
Hirotaka Yamaguchi
Toshi Gobe
Ryuichi Inoue
Toshimitsu Sato
Koichi Niimi
Tomohiko Kobayashi
Shinichi Watanabe
Masato Ozeki
Yoshihiro Igarashi
Kazuya Kawamoto
Masao Haruna
Hirotaka Yamaguchi
Toshi Gobe
Ryuichi Inoue
Toshimitsu Sato
Koichi Niimi
Tomohiko Kobayashi
Shinichi Watanabe
Masato Ozeki
Yoshihiro Igarashi
Kazuya Kawamoto