POLYCYCLIC AMINE COMPOUND, ITS ENANTIOMER, ITS PREPARATION AND PHARMACEUTIC COMPOSITION CONTAINING THOSE

Title:

POLYCYCLIC AMINE COMPOUND, ITS ENANTIOMER, ITS PREPARATION AND PHARMACEUTIC COMPOSITION CONTAINING THOSE

Document Type and Number:

Japanese Patent JP3242980

Kind Code:

B2

Abstract:

PURPOSE: To provide a new polycyclicamine compd. which has pharmaceutically floating properties like a neurokinin receptor antagonist and is useful for the treatment for substance P-dependent and neurokinin-dependent pathological conditions.
CONSTITUTION: The compd. is expressed by formula I, wherein Y is Cy-N, Cy-CH2-N, Ar-(CH2)x-CX (Cy is phenyl, cycloalkyl, etc., which may have substituents; Ar is phenyl, pyridyl, etc., which may have substituents; (x) is 0 or 1; X is H, OH, alkoxy, acyloxy, CN, etc.); (m) is 2, 3; Ar' is phenyl, thienyl, naphthyl, etc., which may have substituents; (n) is 0 to 3; (p) is 1, 2; Q is 0 or two H; T is CO, CH2; (q) is 0 to 3; Z is phenyl or naphthyl which may have substituents, or pyridinyl, indolyl, etc. The compd. is, form example, 5-[2-(4- benzylpiperidin-1-yl)ethyl]-5-(3,4-dichlorophenyl)-1-benzylpiperidinone salt. The compd. of formula I with T being CO is obtd. by the reaction of a compd. expressed by formula I and a compd. expressed by formula III.

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Inventors:

Xavier Emon-Alto
Patrick Gale
Bansanzo Proiette
Pierre Gourwick

Application Number:

JP11382092A

Publication Date:

December 25, 2001

Filing Date:

May 06, 1992

Export Citation:

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Assignee:

SANOFI-SYNTHELABO

International Classes:

A61K31/4427; A61K31/4433; A61K31/4465; A61K31/4468; A61K31/451; A61K31/4523; A61K31/454; A61P1/00; A61P9/00; A61P11/00; A61P29/00; A61P37/08; A61P43/00; C07D205/02; C07D207/06; C07D207/08; C07D207/12; C07D207/26; C07D211/08; A61K31/445; C07D211/18; C07D211/22; C07D211/24; C07D211/26; C07D211/34; C07D211/44; C07D211/52; C07D211/58; C07D211/74; C07D211/76; C07D223/04; C07D223/08; C07D225/00; C07D401/04; C07D401/06; C07D401/12; C07D401/14; C07D403/06; C07D403/14; C07D405/06; C07D405/12; C07D405/14; C07D409/04; C07D409/06; C07D409/14; C07D; (IPC1-7): C07D211/26; A61K31/445; A61K31/4523; A61K31/454; A61P1/00; A61P9/00; A61P11/00; A61P29/00; A61P37/08; A61P43/00; C07D211/44; C07D211/58; C07D211/76; C07D401/04; C07D401/06; C07D401/12; C07D401/14; C07D409/04; C07D409/14

Attorney, Agent or Firm:

Takehiko Suzue

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