Title:
PREPARATION OF HEXAHYDROISOQUINOLINES FROM DIHYDROISOQUINOLINES
Document Type and Number:
Japanese Patent JP2013100367
Kind Code:
A
Abstract:
To provide processes for the synthesis of intermediates used to prepare morphinans.
The present invention is directed to processes for the synthesis of morphinans. In particular, a process for the asymmetric reduction of an imine moiety in a 3,4-dihydroisoquinoline to produce a tetrahydroisoquinoline, followed by a Birch reduction to produce a hexahydroisoquinoline. In various embodiments, the 3,4-dihydroisoquinoline contains a phenol moiety protected with a labile protecting group. In other embodiments, the imine reduction reaction mixture contains silver tetrafluoroborate.
Inventors:
WANG PETER X
CANTRELL GARY L
MAGPARANGALAN DAN P
MOSER FRANK W
BAO JIAN
GROTE CHRISTOPHER W
CANTRELL GARY L
MAGPARANGALAN DAN P
MOSER FRANK W
BAO JIAN
GROTE CHRISTOPHER W
Application Number:
JP2013037044A
Publication Date:
May 23, 2013
Filing Date:
February 27, 2013
Export Citation:
Assignee:
MALLINCKRODT LLC
International Classes:
C07D217/20; C07B53/00; C07B61/00
Attorney, Agent or Firm:
Takeshi Oshio
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