Title:
PREPARATION METHOD OF 2-HYDROXYMETHYL-2,3-DIHYDRO-THIENO[3,4-b][1,4]DIOXIN
Document Type and Number:
Japanese Patent JP2015067606
Kind Code:
A
Abstract:
PROBLEM TO BE SOLVED: To provide a preparation method that can produce 2-hydroxymethyl-2,3-dihydro-thieno[3,4-b][1,4]dioxin in high yield without performing complicated purification.SOLUTION: Provided is a 2-hydroxymethyl-2,3-dihydro-thieno[3,4-b][1,4]dioxin preparation method that includes: a step of hydrolysis process in which 3,4-dihydroxy-thiophene-2,5-dicarboxylic acid dialkyl ester and halogenated propanol are allowed to react in the presence of a weak base to yield 2-hydroxymethyl-2,3-dihydro-thieno[3,4-b][1,4]dioxin-5,7-dicarboxylic acid, or a mixture of dialkyl ester thereof, followed by hydrolyzing the same with a strong base to yield only dicarboxylic acid derivatives; and in succession a step of decarbonating the same in the presence of a copper catalyst to yield 2-hydroxymethyl-2,3-dihydro-thieno[3,4-b][1,4]dioxin of the formula.
Inventors:
AWANO YUTAKA
NISHIYAMA SHOICHI
YANO YUICHI
NISHIYAMA SHOICHI
YANO YUICHI
Application Number:
JP2013206464A
Publication Date:
April 13, 2015
Filing Date:
October 01, 2013
Export Citation:
Assignee:
TOSOH CORP
International Classes:
C07D495/04
Domestic Patent References:
| JP2014201545A | 2014-10-27 | |||
| JP2003335781A | 2003-11-28 |
Foreign References:
| US5111327A | 1992-05-05 |