To provide a method for treating and preventing androgen deficiency.

(1) A method for treating androgen deficiency causing osteroporesis and/or fracture and/or bone mineral concentration decrease, (2) a method for preventing the androgen deficiency, (3) a method for inhibiting or suppressing the androgen deficiency, and (4) a method for reducing the progressive risk of the androgen deficiency, each comprises administering an anti-estrogen agent and/or its analog, derivative, isomer, metabolite, pharmaceutically acceptable salt, medicine, hydrate, N-oxide or their arbitrary combination into a male patient suffered from prostatic cancer.