Title:
PRODUCTION OF 3-BUTENE-1-OL DERIVATIVE
Document Type and Number:
Japanese Patent JP2000169407
Kind Code:
A
Abstract:
To obtain the subject derivative useful as an intermediate for a medicine in excellent selectivity in a high yield by using a carbonyl-ene reaction in the presence of an inexpensive and readily obtainable trifluoroborane compound and an aluminosilicate.
A compound of formula [R1 is a 1-6C alkyl, a 3-6C cycloalkyl, a (substituted) 6-10C aryl or the like] is reacted with a compound of formula II (R2 is H, a 1-6C alkoxycarbonyl, a 1-6C alkyl, a 1-6C halogenated alkyl or the like) in the presence of a trifluoroborane compound (preferably trifluoroborane 1-4C alkyl ether complex, etc.), and an aluminosilicate (preferably synthetic zeolite, etc.), to give a compound of formula III such as 3-(3,4- dichlorophenyl)-3-butene-1-ol, etc.
Inventors:
OKAJI TAKAHIRO
FUJIMOTO KATSUHIKO
TAKEBAYASHI TOYONORI
FUJIMOTO KATSUHIKO
TAKEBAYASHI TOYONORI
Application Number:
JP35128498A
Publication Date:
June 20, 2000
Filing Date:
December 10, 1998
Export Citation:
Assignee:
SANKYO CO
International Classes:
B01J31/22; C07B61/00; C07C29/44; C07C33/30; C07C33/40; C07C45/69; C07C205/14; C07C255/15; C07F5/02; (IPC1-7): C07C29/44; B01J31/22; C07C33/30; C07C33/40; C07C45/69; C07C205/14; C07C255/15; C07F5/02
Attorney, Agent or Firm:
Akio Ohno (2 outside)
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