Title:
PRODUCTION OF 3-(DIARYLMETHYLENE) OXYINDOLE DERIVATIVE
Document Type and Number:
Japanese Patent JP3696330
Kind Code:
B2
Abstract:
PROBLEM TO BE SOLVED: To produce 3-(diarylmethylene) oxyindole derivative having suppressing activity on vascular intima thickening, etc., in a safe, economical, simple and effective manner by reacting an oxyindole with a ketone using a specific base, solvent and condition.
SOLUTION: An oxyindole of formula I [R is H, a (substituted) lower alkyl or a (substituted) benzyl] or its derivative is made to react with a ketone of formula II [R1 and R2 are each a (substituted) aryl] in the presence of an alkali metal hydroxide in toluene or t-amyl alcohol under dehydration refluxing to obtain 3-(diarylmethylene) oxyindole derivative of formula III. For example, oxyindole, 4,4'-dimethylbenzophenone and 85% potassium hydroxide are made to react in toluene to obtain 3-[bis (4-methylphenyl) methylene] oxyindole.
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Inventors:
Atsushi Sato
Takuya Asao
Takuya Asao
Application Number:
JP9710196A
Publication Date:
September 14, 2005
Filing Date:
April 18, 1996
Export Citation:
Assignee:
Taiho Pharmaceutical Co., Ltd.
International Classes:
A61K31/40; A61K31/403; A61K31/404; A61P9/00; A61P9/10; A61P43/00; B01J23/02; B01J23/04; C07B61/00; C07D209/34; (IPC1-7): C07D209/34; B01J23/04
Domestic Patent References:
| JP6501494A |
Foreign References:
| WO1995014667A1 |
Attorney, Agent or Firm:
Miyuki Ariga
Toshio Takano
Toshio Nakajima
Hiromi Matoba
Toshio Takano
Toshio Nakajima
Hiromi Matoba