Title:
PRODUCTION OF ALPHA, BETA-SUBSTITUTED CYCLOPENTANONE DERIVATIVE
Document Type and Number:
Japanese Patent JP3304477
Kind Code:
B2
Abstract:
PURPOSE: To obtain the subject compound as an intermediate for prostaglandins in a high yield and through short steps under neutral and mild conditions without troubles such as preparing unstable anionic reagent (s).
CONSTITUTION: The compound of formula V can be obtained by reaction, in the presence of a radical generator, between (A) a substituted cyclopentanone derivative of formula {X is (αOZ, β-H) or (α-H, β-OZ) (Z is OH-protecting group), Y is (-α-H, β-R) or (α-R, β-H) [ R is formula II (T is CH2CH2 or CH=CH; (j) and (k) each 0-2; R0 is H, alkyl or alkoxy; R1 is alkyl, cycloalkyl, alkenyl, alkynyl, phenyl, phenoxy, etc.)]} and (B) a compound of formula III [A is halogen or formula IV (Rx is H, alkyl, aryl, etc.); R2-R8 are each H, alkyl or alkoxyl; R9 is H, alkyl, halogen, CN, NH2, etc.; U is T, C≡C, phenylene, etc.; (l) is 1-7; (m), (p) and (r) are each 0 or 1; (n), (q) and (s) are each 0-5; X1 and X2 are each 0 or S; Z1 is CN, OH, H, halogen, etc.], followed by, if desired, hydrolysis.
Inventors:
Fumie Sato
Application Number:
JP5483393A
Publication Date:
July 22, 2002
Filing Date:
February 19, 1993
Export Citation:
Assignee:
Fumie Sato
Nissan Chemical Industry Co., Ltd.
Nissan Chemical Industry Co., Ltd.
International Classes:
C07C405/00; (IPC1-7): C07C405/00
Domestic Patent References:
| JP4120044A | ||||
| JP50101337A | ||||
| JP63316786A | ||||
| JP6116233A | ||||
| JP665194A | ||||
| JP6192219A |
Attorney, Agent or Firm:
Takashi Kojima