To produce the subject high-purity compound useful as a synthetic intermediate for medicines such as an antiinflammatory agent, agrochemical, dyes, polymers, etc., in high yield by reacting N-phenyl-substituted amides with benzoic acids or benzyol halides.
A compound represented by formula I (R is an acyl or silyl; ring A may have 1-4 substituent groups at positions other than the 2-position) [N-(3,4-dimethoxyphenyl)acetamide is especially preferred] is reacted with a compound represented by formula II (Y is hydroxyl or a halogen; ring B may have 1-4 substituent groups) (3,4-dimethoxybenzoic acid is especially preferred), preferably in the presence of a Friedel-Crafts reactional catalyst and a phosphorus halide compound in an organic solvent such as a halogenated hydrocarbon at about 40-50°C for 12-16hr to produce the objective compound represented by formula III.
YAMASHITA MAKOTO
KURODA KAZUNORI
