Title:
PRODUCTION OF OPTICALLY ACTIVE 1-OCTEN-3-OL
Document Type and Number:
Japanese Patent JP3638643
Kind Code:
B2
Abstract:
PURPOSE: To simply obtain the subject compound in high asymmetric selectivity by reacting 1-octen-3-ol with an acyl donor in the presence of a lipase.
CONSTITUTION: 1-octen-3-ol (hereinafter referred to as matsutakeol) is reacted with an acyl donor such as an alkyl ester, an alkenyl ester, an acid anhydride, etc., of a carboxylic acid in the presence of a lipase, especially a lipase derived from Candida antarctica in a solvent (e.g. hexane) at 4-80°C. An unreacted material is separated from a mixture containing the resultant acylated material and the unreacted material to afford (R)-matsutakeol and the acylated material is hydrolyzed to provide (S)-matsutakeol. The lipase is used in an amount of 0.1-10wt.%.
Inventors:
Oshikubo Shigemasa
Nozaki Rinsei
Nozaki Rinsei
Application Number:
JP27573494A
Publication Date:
April 13, 2005
Filing Date:
October 14, 1994
Export Citation:
Assignee:
Takasago International Corporation
International Classes:
C12P7/00; C07B57/00; C07C27/02; C07C29/88; C07C33/03; C12P7/04; C12P41/00; C12R1/72; (IPC1-7): C07C29/88; C07B57/00; C07C27/02; C07C33/03; C12P7/04; C12P41/00
Domestic Patent References:
| JP4349894A | ||||
| JP6165694A | ||||
| JP4266885A | ||||
| JP6269294A |
Other References:
野崎倫生,化学,1993, Vol.48, No.12,p.814-816
Attorney, Agent or Firm:
Kazuo Watanabe
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