薬物の時間放出のためのプログラム可能な医薬組成物

Japanese Patent JP7195345

B2

The present disclosure provides programmable osmotic-controlled oral compositions providing delayed release of a therapeutically acceptable amount of a drug. In certain embodiments, the programmable osmotic-controlled compositions of the disclosure provide a lag time that is independent of the presence or absence of food, type of food, pH, gastric emptying, and volume of gastric fluid. The programmable osmotic-controlled oral compositions of the disclosure comprise a multilayer core comprising a drug for controlled release, wherein the core is coated with a semipermeable membrane comprising an orifice and, optionally, an immediate release coating, comprising a drug for immediate release, over the semipermeable membrane. The multilayered core comprises a pull layer containing the drug and a push layer. The pull layer comprises at least two layers: a placebo layer for providing a desired lag time for the drug release; and an active layer containing the drug and providing a delayed controlled release of the drug. The compositions of the disclosure can be programmed to provide a desired and precise lag time, and release drug, after the lag time, at a rhythm, e.g., that matches the human circadian rhythm of a condition's symptoms and/or of the individual being treated in the application of the therapy to optimize therapeutic outcome and minimize side effects.

Vagasha, Jai Deep
Shah, Nabnit H.
Fur Pradito, Wantany
Desai, Depend
Vaka, Shiva Ram Kiran
Tonsakumak, Atosawin

JP2020570408A

December 23, 2022

March 05, 2019

Click for automatic bibliography generation  

Amneil Complex Products Research LLC

A61K9/24; A61K47/02; A61K47/10; A61K47/26; A61K47/32; A61K47/34; A61K47/38

US5156850

Patent Attorney Corporation Hiroe Associates Patent Office

Previous Patent: Forced gap insertion for pervasive listening

Next Patent: DEVICE FOR FILLING MAGNETIC POWDER