NEW MATERIAL:Prostaglandin I2 analog compound I (Y is ethylene, trans- venylene; R1 is H, 1-12C alkyl; R2 is H, methyl, etc.; R3 is single bond, 1-4C alkylene; R4 is H, 1-8C alkyl, etc.; wary line is α,β,α+β-cordination; C5=C5 is Z); their cyclodextrin-clathrate compound, and when R1 is H, non-toxic salts of the acid.
EXAMPLE: (5Z,13E)-(9α,11α,15S)-6,9-eptithio-11,15-dihydroxyprosta-5,13-dienoic acid methyl ester.
USE: The compounds have arthery relaxing effect and esp. human blood platelet coagulation inhibiting effect, and useful as remedies for artheriosclerosis, cardiac infarction, thrombosis,etc.
PROCESS: The compound I is prepared by converting the C9-OH of a compound II (R5 is H, 1-4C alkyl; R7 is benzoyl, etc.) to alkylsulfonyl, reacting with a compound III (R6 is 1-4C lakyl; Q is O, S), and further reacting under conditions.
ARAI YOSHINOBU
SHIMOJI KATSUICHI
