Title:
ＥＲＧ遺伝子発現における前立腺癌特異的変化ならびにそれらの変化に基づく検出および治療方法
Document Type and Number:
Japanese Patent JP5781922
Kind Code:
B2
Abstract:
Alterations in ERG gene expression can be observed in patients with prostate cancer. Specific ERG isoforms are associated with, or involved in, prostate cancer. Compositions comprising these isoforms provide therapeutic benefit and can be used in methods of detecting, diagnosing, prognosing, and treating prostate cancer. These compositions provide biomarkers for detecting the expression of combinations of the PSA/KLK3, PMEPA1, NKX3.1, 0DC1, AMD1, and ERG genes.
Inventors:
Shrivastava, Shiv
Dovi, Albert
Threenas, Tadur
Petrovics, George
Sun, Chen
Dovi, Albert
Threenas, Tadur
Petrovics, George
Sun, Chen
Application Number:
JP2011503948A
Publication Date:
September 24, 2015
Filing Date:
April 10, 2008
Export Citation:
Assignee:
The Henry M. Jackson Foundation For The Advancement Of Military Medicine, Incorporated
International Classes:
C12N15/09; A61K31/7088; A61K48/00; A61P35/00; C12N15/113; C12Q1/68; G01N33/50
Domestic Patent References:
| JP2007535939A |
Foreign References:
| US20050272080 | ||||
| WO2007033187A1 |
Other References:
SEQ ID NO 636076,Publication Site for Issued and Published Sequences (PSIPS),2005年12月 8日,URL,http://seqdata.uspto.gov/?pageRequest=viewSequence&DocID=20050272080&seqID=636076
SRIVASTAVA, S.,Structure and Function of the Splice Variants of TMPRSS2-ERG, a Prevalent Genomic Alteration in Prostate Cancer,DEFENSE TECHNICAL INFORMATION CENTER,2012年 9月,URL,http://www.dtic.mil/get-tr-doc/pdf?AD=ADA566991
J. Mol. Diagn., 2008 Jan;10(1):p.50-57
Oncogene, 2007 Apr 19;26(18):p.2667-2673
Mod. Pathol., 2007 Sep;20(9):p.921-928
Gene, 2004 Jan 7;324:p.65-77
SRIVASTAVA, S.,Structure and Function of the Splice Variants of TMPRSS2-ERG, a Prevalent Genomic Alteration in Prostate Cancer,DEFENSE TECHNICAL INFORMATION CENTER,2012年 9月,URL,http://www.dtic.mil/get-tr-doc/pdf?AD=ADA566991
J. Mol. Diagn., 2008 Jan;10(1):p.50-57
Oncogene, 2007 Apr 19;26(18):p.2667-2673
Mod. Pathol., 2007 Sep;20(9):p.921-928
Gene, 2004 Jan 7;324:p.65-77
Attorney, Agent or Firm:
Yusuke Hiraki
Satoshi Fujita
Eiichi Arai
Natsuo Tanaka
Kosemura Akiko
Satoshi Fujita
Eiichi Arai
Natsuo Tanaka
Kosemura Akiko