Title:
タウプロテインキナーゼ1阻害剤としてのピリミドン誘導体
Document Type and Number:
Japanese Patent JP5535310
Kind Code:
B2
Abstract:
A compound represented by the formula (I) or a pharmaceutically acceptable salt thereof: wherein Z represents nitrogen atom or C—X; X represents hydrogen atom or fluorine atom; R1 is hydrogen atom or a C1-C3 alkyl group; L represents single bond or a C1-C6 alkylene group which may be substituted; Y represents single bond, sulfur atom, oxygen atom, NH, or the like; R2 represents hydrogen atom or a cyclic group which may be substituted, which is used for preventive and/or therapeutic treatment of a disease caused by abnormal activity of tau protein kinase 1 such as a neurodegenerative diseases (e.g. Alzheimer disease).
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Inventors:
Kazuki Nakayama
Daiki Sakai
Kazutoshi Watanabe
Toshiyuki Ohara
Keiichi Aritomo
Daiki Sakai
Kazutoshi Watanabe
Toshiyuki Ohara
Keiichi Aritomo
Application Number:
JP2012507488A
Publication Date:
July 02, 2014
Filing Date:
August 11, 2010
Export Citation:
Assignee:
Mitsubishi Tanabe Pharma Corporation
SANOFI
SANOFI
International Classes:
C07D239/52; A61K31/506; A61K31/536; A61K31/5377; A61K31/55; A61P3/04; A61P3/10; A61P7/00; A61P9/10; A61P17/02; A61P17/14; A61P21/02; A61P25/00; A61P25/02; A61P25/14; A61P25/16; A61P25/18; A61P25/24; A61P25/28; A61P27/02; A61P27/06; A61P33/06; A61P35/00; A61P35/02; A61P43/00; C07D401/04; C07D401/14; C07D403/14; C07D409/14; C07D413/14; C07D471/08
Domestic Patent References:
| JP2002525366A | ||||
| JP2006510684A | ||||
| JP2005510472A | ||||
| JP2008512347A |
Foreign References:
| WO2003037888A1 |
Attorney, Agent or Firm:
Patent Service Corporation Patent Office Sykes