Title:
化学修飾されたカプシドを有するＲＡＡＶ
Document Type and Number:
Japanese Patent JP7100629
Kind Code:
B2
Abstract:
The invention is directed to a recombinant Adeno-Associated Virus (rAAV) vector particle having at least one primary amino group contained in the capsid proteins, chemically coupled with at least one ligand L, wherein coupling of said ligand L is implemented through a bond comprising a —CSNH— bond and an optionally substituted aromatic moiety. The present invention further relates to a method for chemically coupling an Adeno-Associated Virus (AAV) vector particle with at least one ligand L and to a Recombinant Adeno-Associated Virus (rAAV) vector particle obtained by said method as well as a pharmaceutical composition comprising it and their corresponding medical use.
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Inventors:
Mevelle, Mathieu
David, Denio
Ayuzo, Eduard
David, Denio
Ayuzo, Eduard
Application Number:
JP2019517161A
Publication Date:
July 13, 2022
Filing Date:
June 09, 2017
Export Citation:
Assignee:
Center National de la Recherche Scientific
Anstitut National de la Sante Ede la Rechelche Medical (Anselm)
Universite Donant
Center Hospitalie Universitaire Donant
Anstitut National de la Sante Ede la Rechelche Medical (Anselm)
Universite Donant
Center Hospitalie Universitaire Donant
International Classes:
C12N15/864; A61K35/76; A61K47/54; A61K47/60; A61K47/64; A61K48/00; A61P1/16; A61P3/00; A61P7/00; A61P9/04; A61P21/00; A61P25/00; A61P27/02; A61P35/00; A61P37/02
Foreign References:
| WO2005106046A1 | ||||
| WO2015048534A1 |
Other References:
Kye-Il J. et al.,ACS NANO,2011年,Vol. 5, No. 5,p. 3523-3535
Wobus C. E. et al.,Journal of Virology,2000年,Vol. 74, No. 19,p. 9281-9293
Wobus C. E. et al.,Journal of Virology,2000年,Vol. 74, No. 19,p. 9281-9293
Attorney, Agent or Firm:
Mitsuo Matsui
Hiroshi Murakami
Hiroshi Murakami
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