Title:
RHOキナーゼインヒビター
Document Type and Number:
Japanese Patent JP5258790
Kind Code:
B2
Abstract:
Substituted amide and urea derivatives useful as inhibitors of Rho kinase are described, which inhibitors can be useful in the treatment of various disorders such as cardiovascular diseases, cancer, neurological diseases, renal diseases, bronchial asthma, erectile dysfunction and glaucoma.
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Inventors:
Derman george
Hicky Eugene Richard
Lisian
Mao Wan
Marshall Daniel Richard
Morwick Tina Marie
Sibley Robert
Snow Roger John
Solsec Ronald John
Woo Frank
Young Eric Richard Ruche
Hicky Eugene Richard
Lisian
Mao Wan
Marshall Daniel Richard
Morwick Tina Marie
Sibley Robert
Snow Roger John
Solsec Ronald John
Woo Frank
Young Eric Richard Ruche
Application Number:
JP2009544958A
Publication Date:
August 07, 2013
Filing Date:
January 02, 2008
Export Citation:
Assignee:
Boehringer Ingelheim International GmbH
International Classes:
C07C237/42; A61K31/166; A61K31/167; A61K31/17; A61K31/277; A61K31/341; A61K31/40; A61K31/4035; A61K31/415; A61K31/4196; A61K31/426; A61K31/428; A61K31/437; A61K31/4375; A61K31/439; A61K31/4458; A61K31/4462; A61K31/4465; A61K31/472; A61K31/4725; A61K31/496; A61K31/5375; A61K31/5377; A61K31/541; A61K31/55; A61P1/04; A61P9/04; A61P9/10; A61P9/12; A61P11/06; A61P13/12; A61P15/10; A61P17/06; A61P19/02; A61P25/00; A61P25/04; A61P25/28; A61P27/06; A61P29/00; A61P35/00; A61P43/00; C07C255/57; C07C275/30; C07C275/34; C07C275/42; C07C323/62; C07D207/04; C07D209/44; C07D211/26; C07D215/48; C07D217/22; C07D217/26; C07D223/16; C07D231/12; C07D249/08; C07D277/20; C07D277/54; C07D277/82; C07D285/135; C07D295/08; C07D295/12; C07D307/68; C07D417/04; C07D471/04; C07D498/04; C07D513/04; C07D513/18
Domestic Patent References:
| JP11139969A | ||||
| JP2000510865A |
Foreign References:
| WO2005074643A2 | ||||
| WO2001056988A1 | ||||
| WO2005058891A1 |
Other References:
Edvinsson, Karin M.; Herslof, Margareta; Holm, Patrik; Kann, Nina; Keeling, David J.; Mattsson, Jan P.; Norden, Bo; Shcherbukhin, Vladimir,Solid phase synthesis of diamides as potential bone resorption inhibitors,Bioorganic and Medicinal Chemistry Letters,NL,2000年,10(5),503-507
Attorney, Agent or Firm:
Sadao Kumakura
Nobuo Ogawa
Atsushi Hakoda
Kenji Asai
Kazuo Yamazaki
Nobuo Ogawa
Atsushi Hakoda
Kenji Asai
Kazuo Yamazaki
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