Title:
SHORT-ACTING HEPARIN-BASED ANTICOAGULANT COMPOUNDS AND METHODS
Document Type and Number:
Japanese Patent JP2023166387
Kind Code:
A
Abstract:
To provide synthetic heparin analogues having anticoagulant activity, provide cost-effective methods of synthesizing a new synthetic heparin, and further provide methods of treating a subject in need of anticoagulant activity.SOLUTION: A synthetic heparin analogue comprises: (a) 3-O-sulfated oligosaccharide comprising six to eight saccharide units; (b) at least one disaccharide unit sulfated by a 3-OST-3 enzyme; and (c) at least one ldoA2S-GlcNS3S or ldoA2S-GlcNS3S6S disaccharide unit.SELECTED DRAWING: Figure 1A
Inventors:
LIU JIAN
WANG ZHANGJIE
HSIEH PO-HUNG
XU YONGMEI
WANG ZHANGJIE
HSIEH PO-HUNG
XU YONGMEI
Application Number:
JP2023129964A
Publication Date:
November 21, 2023
Filing Date:
August 09, 2023
Export Citation:
Assignee:
UNIV NORTH CAROLINA CHAPEL HILL
International Classes:
C08B37/10; A61K31/727; A61K38/02; A61P7/02; A61P43/00; C12P19/04
Attorney, Agent or Firm:
Sonoda & Kobayashi Patent Attorneys Corporation