SINGLE AMINO ACID MUTATED PROTEIN OF HISTONE H3, ITS MUTANT CELL AND USE THEREOF

Title:

SINGLE AMINO ACID MUTATED PROTEIN OF HISTONE H3, ITS MUTANT CELL AND USE THEREOF

Document Type and Number:

Japanese Patent JP3868985

Kind Code:

B2

Abstract:

PROBLEM TO BE SOLVED: To provide a new yeast cell strain having a new acquired character without directly operating a gene encoded by a genom DNA or its transcription product by introducing a single amino acid mutation to histone H3 or H4 and provide the use of the strain.
SOLUTION: The invention relates to a mutant yeast cell expressing a mutant histone H3 protein or histone H4 protein having a specific single amino acid residue substituted with alanine residue, a mutant histone protein of the cell, a polynucleotide encoding the mutant protein and a method for using the cell, protein and polynucleotide.

Inventors:

Takashi Umehara
Kazuko Matsubara
Horikoshi Masami

Application Number:

JP2005372853A

Publication Date:

January 17, 2007

Filing Date:

December 26, 2005

Export Citation:

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Assignee:

Japan Science and Technology Agency

International Classes:

C12N15/09; C07K14/39; C12N1/19; C12Q1/02

Domestic Patent References:

JP2006109845A

Other References:

Mol. Cell. Biol., 1996, Vol.16, p.1017-1026
The EMBO Journal, 1997, Vol.16, p.2493-2506
Genes Dev., 1995, Vol.9, p.2770-2779
The Journal of Biological Chemistry, 1991, Vol.266, p.6489-6498
The Journal of Biological Chemistry, 1993, Vol.268, p.1118-1124
Mol. Cell. Biol., 1990, Vol.10, p.4932-4934

Attorney, Agent or Firm:

Toshio Nishizawa

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