Title:
Spectrum imaging for measuring the core pathological feature of the cancer cell prepared for in Sites analysis
Document Type and Number:
Japanese Patent JP6208121
Kind Code:
B2
Abstract:
In general, the presently disclosed technology relates to identification of cancer subtypes. More specifically, the technology relates to methods for determining molecular drivers of cancer and/or progression using a multivariate image data and statistical analysis of in-situ molecular markers and morphological characteristics in the same cells of a biological sample suspected of b cancer. This analysis takes place after a single acquisition that obtains the molecular and anatomic morphology data in parallel. The analysis compares specific morphological and molecular markers to known samples exhibiting particular genetic drivers of the cancer. This method provides statistical information that allows for an increased confidence in the identification of specific molecular drivers of the cancer.
Inventors:
Demichelis, Francesca
Karsha, Garcia
Mirror, philippe sea
Nagle, Ray Bee
Otter, Michael
Pestano, Gary Anthony
Rubin, Mark A.
Karsha, Garcia
Mirror, philippe sea
Nagle, Ray Bee
Otter, Michael
Pestano, Gary Anthony
Rubin, Mark A.
Application Number:
JP2014509698A
Publication Date:
October 04, 2017
Filing Date:
May 07, 2012
Export Citation:
Assignee:
Ventana Medical Systems, Inc.
CORNELL UNIVERSITY
CORNELL UNIVERSITY
International Classes:
C12Q1/68; C12M1/34; C12N15/09; G01N33/48; G16B20/00; G16B20/20
Domestic Patent References:
| JP2010537201A |
Foreign References:
| US5989811 |
Other References:
Modern Pathology,2008年,Vol.21,p.1451-1460
British Journal of Cancer,2010年,Vol.102,p.678-684
Clin Cancer Res,2009年,Vol.15, No.14,p.4706-4711
The Journal of Urology,2000年,Vol.164,p.1768-1775
American Journal of Pathology,1992年,Vol.141, No.4,p.797-804
Mutation Research,2010年,Vol.683,p.16-22
日本産科婦人科学会雑誌,1997年,Vol.49, No.3,p.160-166
医学のあゆみ,1996年,Vol.179, No.7,p.446-447
Laboratory Investigation,2010年,Vol.90,p.195A,864
Genes Chromosomes & Cancer,1997年,Vol.18,p.228-231
日経バイオテク/日経バイオビジネス編集,日経バイオ最新用語辞典,日経BP社発行,2002年,第5版,65頁
British Journal of Cancer,2010年,Vol.102,p.678-684
Clin Cancer Res,2009年,Vol.15, No.14,p.4706-4711
The Journal of Urology,2000年,Vol.164,p.1768-1775
American Journal of Pathology,1992年,Vol.141, No.4,p.797-804
Mutation Research,2010年,Vol.683,p.16-22
日本産科婦人科学会雑誌,1997年,Vol.49, No.3,p.160-166
医学のあゆみ,1996年,Vol.179, No.7,p.446-447
Laboratory Investigation,2010年,Vol.90,p.195A,864
Genes Chromosomes & Cancer,1997年,Vol.18,p.228-231
日経バイオテク/日経バイオビジネス編集,日経バイオ最新用語辞典,日経BP社発行,2002年,第5版,65頁
Attorney, Agent or Firm:
Sonoda/Kobayashi Patent Business Corporation
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