To provide a method which is for targeting a therapeutic agent on a cellular partition and which is novel, more simple, more efficient, and more costly effective.
By providing a targeted protein therapeutic agent for localizing cells requiring a therapeutic agent in a subcellular partition, the treatment of metabolic disorder is facilitated. By decreasing the necessity of processing after translation or processing after elaboration of the protein, the preparation of the targeting protein therapeutic agent is simplified. By this invention, a targeting therapeutic agent, such as lysosome, locally existing in a subcellular partition is provided. The targeting therapeutic agent includes a therapeutic drug and a target-nature portion bonded to a receptor on the outside surface of a cell, and in internalization of the receptor, suitable subcellular localization of the targeting therapeutic agent is enabled. Nucleic acid, a cell, and the method are also provided.
BEVERLEY STEPHEN M
JPN7009001620; Ｊ． ＢＩＯＬ． ＣＨＥＭ． ２７０（３０）, 1995, Ｐ．１８０１３-１８０１８
JPN6009014227; ＢＩＯＣＨＥＭ． ＢＩＯＰＨＹＳ． ＲＥＳ． ＣＯＭＭＵＮ． １８１（２）, 1991, Ｐ．９０７-９１４
JPN7009001621; Ｊ． ＢＩＯＬ． ＣＨＥＭ． ２６６（３１）, 1991, Ｐ．２０６２６-２０６３５
JPN6009014228; ＨＯＲＭ． ＭＥＴＡＢ． ＲＥＳ． ３１（２-３）, 1999, Ｐ．２４２-２４６
JPN7009001616; Ｊ． ＢＩＯＬ． ＣＨＥＭ． ２７４（２）, 1999, Ｐ．１１６４-１１７１
Takaaki Yasumura
Natsuki Morishita