SUBSTITUTED DIHYDROPYRAZOLONES FOR TREATING CARDIOVASCULAR AND BLOOD DISORDERS

Japanese Patent JP2011006486

A

To provide a new compound usable for treating disorders, in particular, cardiovascular and blood disorders.

The invention provides the followings: dihydropyrazolone derivatives represented by formula (I) and their production method; use of them for treating and/or preventing disorders; and use of them for production of medicines for treatment and/or prevention of disorders, in particular cardiovascular and blood disorders, and renal disorders, and for facilitation of wound healing. The compound acts as a specific inhibitor against HIF prolyl 4-hydroxylase and brings, on the basis of the specific action mechanism, biological processes derived therefrom, for example, induction of HIF target genes such as erythropoietin and, for example, erythropoiesis in vivo, after parenteral or oral administration.

THEDE KAI
FLAMME INGO
OEHME FELIX
ERGUEDEN JENS-KERIM
STOLL FRIEDERIKE
SCHUHMACHER JOACHIM
WILD HANNO
KOLKHOF PETER
BECK HARTMUT
KELDENICH JOERG
AKBABA METIN
JESKE MARIO

JP2010229627A

January 13, 2011

October 12, 2010

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BAYER SCHERING PHARMA AG

C07D401/14; A61K31/427; A61K31/437; A61K31/4439; A61K31/496; A61K31/497; A61K31/506; A61K31/5377; A61K31/541; A61K31/55; A61K31/551; A61K45/00; A61P7/06; A61P9/00; A61P9/04; A61P9/10; A61P9/12; A61P13/12; A61P29/00; A61P31/18; C07D403/14; C07D413/14; C07D417/14; C07D451/02; C07D471/04; C07D487/04

JPH10306077A	1998-11-17
JPS61137878A	1986-06-25
JPH10306077A	1998-11-17
JPS61137878A	1986-06-25

WO2005030121A2	2005-04-07
US20030083351A1	2003-05-01
WO2005030121A2	2005-04-07
US20030083351A1	2003-05-01

Aoyama Aoi
Takuji Yamada
Michiko Matsutani
Mitsutaka Iwasaki
Yasushi Ochiai

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