THIAZOLE DERIVATIVE, ITS PRODUCTION AND COMPOSITION CONTAINING SAME

Title:

THIAZOLE DERIVATIVE, ITS PRODUCTION AND COMPOSITION CONTAINING SAME

Document Type and Number:

Japanese Patent JPS63225374

Kind Code:

A

Abstract:

NEW MATERIAL:The compound of formula I [R1 is (substituted)amino; R2 is H, lower alkyl or aryl; R3 is H, NO2, (substituted)amino, OH or lower alkoxy; A is lower alkylene; Q is H or halogen; dotted line is arbitrary additional bond].

EXAMPLE: 4-[4-(3-Indolyl)piperidinomethyl]-2-propionylaminothiazole.

USE: Useful as an anti-allergic agent for the remedy and prevention of allergic diseases of human and animal.

PREPARATION: The compound of formula I or its salt can be produced e.g. by reacting a compound of formula II or its salt with a compound of formula III (X is eliminable group) or its salt in a conventional solvent optionally in the presence of a base.

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Inventors:

UEDA IKUO
MATSUO MASAAKI
MANABE KOJI
MATSUDA HIROSHI

Application Number:

JP28945086A

Publication Date:

September 20, 1988

Filing Date:

December 04, 1986

Export Citation:

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Assignee:

FUJISAWA PHARMACEUTICAL CO

International Classes:

A61K31/40; A61K31/404; A61K31/425; A61K31/427; C07D417/12; A61K31/44; A61K31/445; A61K31/4523; A61P11/00; A61P27/16; A61P37/08; C07D401/04; C07D401/14; C07D417/14; (IPC1-7): A61K31/44; A61K31/445; C07D417/12; C07D417/14

Attorney, Agent or Firm:

Aoki High

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