Title:
生物活性薬剤送達のための組織微穿孔
Document Type and Number:
Japanese Patent JP5680685
Kind Code:
B2
Abstract:
A method of enhancing the permeability of a biological membrane, including the skin or mucosa of an animal or the outer layer of a plant to a permeant is described utilizing microporation of selected depth and optionally one or more of sonic, electromagnetic, mechanical and thermal energy and a chemical enhancer. Microporation is accomplished to form a micropore of selected depth in the biological membrane and the porated site is contacted with the permeant. Additional permeation enhancement measures may be applied to the site to enhance both the flux rate of the permeant into the organism through the micropores as well as into targeted tissues within the organism.
Inventors:
ジョナサン エイ． エプステイン
Application Number:
JP2013046499A
Publication Date:
March 04, 2015
Filing Date:
March 08, 2013
Export Citation:
Assignee:
日東電工株式会社
International Classes:
A61M35/00; A61K9/00; A61K9/127; A61K31/485; A61K31/56; A61K31/7105; A61K31/711; A61K31/715; A61K31/727; A61K38/00; A61K38/04; A61K38/28; A61K39/395; A61K41/00; A61M37/00; A61N1/30; A61B17/00
Attorney, Agent or Firm:
Takashima 1
Kyoko Doi
Kamata 光宜
Tamura Yasaka child
Kenji Yamamoto
Murata Miyuki
Koike 順造
Hirofumi Toma
Kyoko Doi
Kamata 光宜
Tamura Yasaka child
Kenji Yamamoto
Murata Miyuki
Koike 順造
Hirofumi Toma