Title:
【発明の名称】薬物速度論をベースとする薬物設計ツールおよび方法
Document Type and Number:
Japanese Patent JP2002524809
Kind Code:
A
Abstract:
A secondary compound library produced by a method of screening a compound library or portion thereof by absorption is provided. The method includes a step (i) that screens a primary compound library or portion thereof having a plurality of test samples containing isolated compounds or isolated mixtures of compounds per test sample by generating an in vivo absorption profile for each of the test samples from initial dose data and from in vitro bioavailability data comprising permeability and solubility data for each of the test samples, wherein the absorption profile includes at least one of rate of absorption, extent of absorption, and concentration of a test sample. Step (ii) produces a secondary compound library that includes at least one compound from the primary compound library having a desired absorption profile.
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Inventors:
Grass, George M.
Riesman, Glendy.
Norris, Daniel A.
Cinco, Patrick Jay.
Welli, John Yee.
Riesman, Glendy.
Norris, Daniel A.
Cinco, Patrick Jay.
Welli, John Yee.
Application Number:
JP2000569763A
Publication Date:
August 06, 2002
Filing Date:
September 14, 1999
Export Citation:
Assignee:
Navigation site, Incorporated
International Classes:
G01N33/50; G16C20/62; A01N37/18; A01N43/04; A01N61/00; A61K31/522; A61P31/12; C07B61/00; C07B63/00; C12M1/00; C12M3/00; C12Q1/00; G01N15/00; G01N31/00; G01N33/15; G01N33/48; G01N33/53; G01N33/543; G06F9/455; G06F17/30; G06F17/50; G06G7/60; G06N3/00; G06N7/00; A61K; (IPC1-7): G06F19/00
Attorney, Agent or Firm:
Takashi Ishida (4 others)