【発明の名称】シグマレセプターリガンドおよびその用途

Japanese Patent JPH06509069

A

The invention relates to methods for the treatment of central nervous system disorders, gastrointestinal disorders, drug abuse, angina, migraine, hypertension and depression by administering a pharmaceutical composition comprising an effective amount of certain sigma receptor ligands to a patient in need of such treatment. The invention further relates to novel sigma receptor ligands having high binding to the sigma receptor and pharmaceutical compositions thereof. Unexpectedly, certain of the sigma receptor ligands of the present invention have selectivity for the sigma receptor over the DA, PCP and 5-HT1A receptors.

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JPH10506891	INDUSTRIAL APPLICABILITY [E] A novel method for producing (E) -1-amino-2- (fluoromethylene) -4- (p-fluorophenyl) butane, a novel method for producing an intermediate thereof, and a novel method thereof. A novel method for producing alkali metal salts of intermediates and diformylamides

Glenon, Richard A.

JP50124893A

October 13, 1994

June 26, 1992

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Virginia Commonwealth University

A61K31/135; A61K31/17; A61K31/215; A61K31/275; A61K31/395; A61K31/40; A61K31/435; A61K31/44; A61K31/445; A61K31/4465; A61K31/451; A61K31/495; A61K31/505; A61K31/535; A61K31/5375; A61K31/55; A61P1/00; A61P9/12; A61P25/04; A61P25/06; A61P25/18; A61P25/24; A61P25/26; A61P25/30; A61P43/00; C07C211/08; C07C211/17; C07C211/27; C07C211/28; C07C211/29; C07C211/30; C07C211/42; C07C215/52; C07C217/16; C07C217/48; C07C217/60; C07C219/10; C07C219/12; C07C225/16; C07C229/46; C07C237/06; C07C243/18; C07C255/30; C07C255/58; C07C311/30; C07C317/26; C07C323/23; C07D207/12; C07D209/48; C07D211/14; C07D211/46; C07D211/48; C07D211/52; C07D211/70; C07D223/16; C07D239/42; C07D241/06; C07D265/30; C07D295/02; C07D295/03; C07D295/033; C07D295/06; C07D295/073; C07D295/096; C07D295/108; C07D295/192; C07D317/58; C07D451/02; C07D471/08; (IPC1-7): C07C211/27; A61K31/135; A61K31/17; A61K31/215; A61K31/275; A61K31/395; A61K31/445; A61K31/495; A61K31/535; C07C211/29; C07C211/30; C07C217/48; C07C225/16; C07C229/46; C07C237/06; C07C243/18; C07C255/30; C07C255/58; C07C311/30; C07C317/26; C07C323/23; C07D209/48; C07D211/14; C07D211/48; C07D211/52; C07D211/70; C07D241/06; C07D265/30; C07D295/02; C07D295/06; C07D451/02

Aoyama Ryo (1 person outside)

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