Title:
【発明の名称】プロペンアミド誘導体とカチオン性単量体との共重合物およびその用途
Document Type and Number:
Japanese Patent JP2745343
Kind Code:
B2
Abstract:
PURPOSE:To obtain the title copolymer useful as an animal cell adhesion inhibitor, a substrate for cell culture or the like by copolymerizing a propenamide derivative with a cationic monomer to introduce a tripeptide of Arg-Gly-Asp into the copolymer. CONSTITUTION:A propenamide derivative having an adhesive peptide of formula II (wherein X and Y are each a residue of an amino acid selected from among Ser, Gly, Val, Asn and Pr or a peptide residue; Z is -O- or -NH-; one of R<4> and R<5> is H and the other is 1-11C linear or branched alkylene or the like, and may be substituted; and n is 1-5) as an essential unit at the side chain of formula I [wherein R<1> and R<2> are each H or COOH; R<3> is H, (carboxy) methyl, ethyl or halogen] is copolymerized with a cationic monomer of formula III [wherein R<6> is H, (substituted) 1-3C alkyl; W is Z; R<7> is H, 1-12C linear or branched alkyl or the like which may be substituted with amino, imino, etc., and may further contain a substituent].
Inventors:
Hiroyuki Komazawa
Masayoshi Kojima
Atsushi Ogasa
Masayoshi Kojima
Atsushi Ogasa
Application Number:
JP6616091A
Publication Date:
April 28, 1998
Filing Date:
March 29, 1991
Export Citation:
Assignee:
Fuji Photo Film Co., Ltd.
International Classes:
C07K7/06; A61K38/00; A61K47/48; A61P7/02; A61P35/00; C07K7/08; C07K14/00; C07K14/78; C08F20/26; C08F20/52; C08F220/28; C08F220/60; C12M3/00; C12N5/07; C12N5/071; (IPC1-7): C07K7/06; A61K38/00; A61K47/48; C07K7/08; C07K14/78; C12M3/00; C12N5/06
Other References:
【文献】第11回日本バイオマテリアル学会大会予稿集1989第82頁
Attorney, Agent or Firm:
Minoru Nakamura (7 outside)