Title:
【発明の名称】遺伝子発現プロフィールを利用した疾患状態および治療のモニター方法
Document Type and Number:
Japanese Patent JP2002518003
Kind Code:
A
Abstract:
The present invention provides methods for monitoring disease states in a subject, as well as methods for monitoring the levels of effect of therapies upon a subject having one or more disease states. The methods involve: (i) measuring abundances of cellular constituents in a cell from a subject to obtain a diagnostic profile, (ii) measuring abundances of cellular constituents in a cell of one or more analogous subjects to obtain perturbation response profiles which correlate to a particular disease or therapy, and (iii) determining the interpolated perturbation response profile or profiles which best fit the diagnostic profile. In other aspects, the invention also provides a computer system capable of performing the methods of the invention, databases comprising perturbation response profiles for one or more diseases and/or therapies, and kits for determining levels of disease states and/or therapeutic effects according to the methods of the invention.
Inventors:
Friend, Stefan, H.
Ronald Stoughton
Ronald Stoughton
Application Number:
JP2000554833A
Publication Date:
June 25, 2002
Filing Date:
June 17, 1999
Export Citation:
Assignee:
Rosetta Inpharmatics,Inc.
International Classes:
A01N43/04; A01N61/00; C07H21/04; C12M1/34; C12M3/00; G01D1/16; C12N15/09; C12P21/06; C12Q1/02; C12Q1/68; C12Q1/6886; G01N33/48; G01N33/53; G01N37/00; G06G7/48; C12M; (IPC1-7): C12Q1/02; C12M3/00; C12N15/09; C12Q1/68; G01D1/16; G01N37/00
Domestic Patent References:
| JPH10272000A | 1998-10-13 |
Foreign References:
| WO1999049083A1 | 1999-09-30 | |||
| US5738998A | 1998-04-14 | |||
| US5746204A | 1998-05-05 | |||
| WO1997006277A1 | 1997-02-20 | |||
| US5677125A | 1997-10-14 |
Attorney, Agent or Firm:
Yusuke Hiraki (1 person outside)