TRICYCLIC-TYPE HETEROCYCLE AS BET PROTEIN INHIBITOR

Japanese Patent JP2018008958

A

PROBLEM TO BE SOLVED: To provide a compound which is an inhibitor of BET protein and is useful for treatment of various cancers, autoimmune diseases, inflammatory diseases, virus infection diseases or the like and pharmaceuticals containing the compound.SOLUTION: There are provided a tricyclic-type heterocyclic compound including a compound represented by the following formula as a representative example, and pharmaceuticals containing the compound. Examples of autoimmune diseases and inflammatory diseases to which the pharmaceuticals are useful include, allergy, arthritis, asthma, chronic obstructive pulmonary disease, degenerative joint disease, dermatitis, organ rejection reaction, eczema, hepatitis, inflammatory bowel disease, multiple sclerosis, myasthenia gravis, psoriasis, sepsis, systemic lupus erythematosus, tissue graft rejection, diabetes or the like, and examples of virus infection diseases include infections caused by adenovirus, hepatitis virus, herpes virus, Human Immunodeficiency Virus or the like.SELECTED DRAWING: None

ANDREW P COMBS
SPARKS RICHARD B
TOMAS P MADUSKUIE JR
RODGERS JAMES D

JP2017134538A

January 18, 2018

July 10, 2017

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INCYTE HOLDINGS CORP

C07D471/06; A61K31/4745; A61K31/5383; A61K31/551; A61P1/04; A61P1/16; A61P3/10; A61P7/00; A61P11/00; A61P11/02; A61P11/06; A61P17/00; A61P17/06; A61P19/02; A61P21/04; A61P25/00; A61P29/00; A61P31/04; A61P31/12; A61P31/14; A61P31/18; A61P31/20; A61P31/22; A61P35/00; A61P35/02; A61P37/02; A61P37/06; A61P37/08; A61P43/00; C07D498/06; C07D519/00

JP2004505975A	2004-02-26
JPH08269058A	1996-10-15

Takuji Yamada
Michiko Matsutani
Yasushi Ochiai

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