Title:
URIC ACID EXCRETION PROMOTOR
Document Type and Number:
Japanese Patent JP3175278
Kind Code:
B2
Abstract:
PURPOSE: To obtain an uric acid excretion promotor containing a specific dihydropyridine derivative which has been known to be useful as an antihypertensive agent, peripheral and cerebral vasodilator, therapeutic agent for coronary artery, mild and long acting and reduced in side effects.
CONSTITUTION: The objective uric acid excretion promotor contains a dihydroxypyridine derivative of formula I {R1 to R3 are alkyl, cycloalkyl or alkoxyalkyl; R4 and R5 are H, halogen, nitro, alkyl halide, alkylsulfonyl, halogenated alkoxy, alkylsulfynyl, alkyl, cycloalkyl, alkoxy, etc.; X is vinylene or azomethine; A is alkylene; B is N (R6)(R7), formula II [R6 to R8 are H, alkyl, cycloalkyl, aralkyl, etc.; Ar is aryl or pyridyl; (n) is 0-2)]} or its acid addition salt as an active ingredient. An amount of uric acid in blood is lowered by promoting excretion of uric acid into urine.
Inventors:
Mitsuyoshi Nakajima
Hironobu Watanabe
Hironobu Watanabe
Application Number:
JP7984192A
Publication Date:
June 11, 2001
Filing Date:
April 01, 1992
Export Citation:
Assignee:
Welfide Co., Ltd.
International Classes:
A61K31/435; A61K31/44; A61K31/4422; A61K31/4427; A61K31/444; A61K31/496; A61P3/00; A61P13/12; A61P19/02; A61P19/06; C07D211/90; C07D401/04; C07D401/12; (IPC1-7): A61K31/4422; A61P3/00; A61P13/12; A61P19/02
Domestic Patent References:
| JP63225356A | ||||
| JP63297365A |
Attorney, Agent or Firm:
Hajime Takashima
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