USE OF 6-(3-CHLORO-2-FLUOROBENZYL)-1-[(2S)-1-HYDROXY-3-METHYLBUTAN-2-YL]-7-METHOXY-4-OXO-1,4-DIHYDROQUINOLINE-3-CARBOXYLIC ACID OR SALT THEREOF FOR TREATING RETROVIRUS INFECTION

Japanese Patent JP2011037857

A

To provide a therapeutic agent, a therapeutic composition and kit production of retrovirus infection.

A use of a therapeutically effective amount of 6-(3-chloro-2-fluorobenzyl)-1-[(2S)-1-hydroxy-3-methylbutan-2-yl]-7-methoxy-4-oxo-1, 4-dihydroquinoline-3-carboxylic acid (hereinafter referred to as a compound I) or a pharmaceutically acceptable salt thereof is provided. Further, the use of the compound I or the salt thereof for an inhibitor of integrase activity is provided. The compound I or the salt thereof is also effective in inhibiting replication of a retrovirus resistant to at least one anti-retroviral drug. The compound I or the salt thereof is administered alone or in combination with at least one anti-retroviral drug other than the compound I or the salt thereof. Further, production of a kit containing the compound I or the salt thereof is provided.

MATSUZAKI YUJI
KANO MITSUKI
IKEDA SATORU

JP2010182092A

February 24, 2011

August 17, 2010

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JAPAN TOBACCO INC

A61K31/47; A61K45/00; A61P31/18; A61P43/00; C07D215/56

JP2006001927A

2006-01-05

WO2004046115A1	2004-06-03
WO1999048371A1	1999-09-30
WO2005112930A1	2005-12-01

JPN7010000483; 化学療法の領域 ｖｏｌ．２０，　ｎｏ．７, 2004, ｐ．１０３８-１０４８
JPN7010000484; 医学のあゆみ ｖｏｌ．２１３，　ｎｏ．１０, 2005, ｐ．８９１-９００
JPN7010000485; ＡＮＴＩＶＩＲＡＬ　ＲＥＳＥＡＲＣＨ ｖｏｌ．４６，　ｎｏ．３, 2000, ｐ．２２３-２３２
JPN7010000486; 現代医療 ｖｏｌ．３４，　ｎｏ．５, 2002, ｐ．１１３５-１１４１

Takashima Ichi
Kyoko Doi
Mitsunori Kamata
Yaeko Tamura
Kenji Yamamoto
Murata Miyuki

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