Title:
哺乳類細胞の増殖を治療するためのハロゲン化芳香族の使用
Document Type and Number:
Japanese Patent JP4099226
Kind Code:
B2
Abstract:
The present invention provides methods and product for inhibiting mammalian cell proliferation. Compounds that are anti-mycotics and that inhibit the Ca<++>-activated potassium channel of erythrocytes have been modified for use in the present invention by removing the imidazole group. Such modified compounds typically have at least aromatic groups separated from one another by not more than five atoms, and more typically not more than three atoms. At least one of the aromatic groups is substituted with a chlorine or another functionality with an overall net negative charge. The compounds can be used in connection with, inter alia, treatments for cancer, treatments for arteriosclerotic conditions, treatments for angiogenic conditions and other cell proliferative disorders.
Inventors:
Halperin, Jose
Brunara, carlo
Brunara, carlo
Application Number:
JP51039196A
Publication Date:
June 11, 2008
Filing Date:
September 15, 1995
Export Citation:
Assignee:
President and Fellows of Harvard College
Children's Medical Center Corporation
Children's Medical Center Corporation
International Classes:
A61K31/045; A61K31/03; A61K31/05; A61K31/055; A61K31/075; A61K31/19; A61K31/195; A61P9/00; A61P9/10; A61P17/00; A61P29/00; A61P35/00; A61P43/00; C07C25/06; C07C59/84; C07C33/46
Domestic Patent References:
| JP48035066B1 | ||||
| JP8506594A | ||||
| JP53111027A | ||||
| JP50035123A | ||||
| JP49020191B1 | ||||
| JP48018449B1 | ||||
| JP59143685A | ||||
| JP3261733A | ||||
| JP50140632A | ||||
| JP48098016A |
Foreign References:
| US4584318 | ||||
| EP0052744A1 | ||||
| US3106545 | ||||
| US1967825 |
Other References:
Biochemistry Pharmacology, 1991年, Vol.41, No.12, p.1949-1956
MATOLCSY, G. et al., Neth. J. Plant Pathol., 1977, Vol.83(Suppl. 1), p.39-47
MATOLCSY, G. et al., Neth. J. Plant Pathol., 1977, Vol.83(Suppl. 1), p.39-47
Attorney, Agent or Firm:
Kazuo Shamoto
Shosuke Imai
Tadashi Masui
Tadahiko Kurita
Yasushi Kobayashi
Ken Matsumoto
Shosuke Imai
Tadashi Masui
Tadahiko Kurita
Yasushi Kobayashi
Ken Matsumoto