Title:
ビタミンD類似体
Document Type and Number:
Japanese Patent JP4629309
Kind Code:
B2
Abstract:
Novel vitamin D analogs, markedly active in the fields of cell proliferation and differentiation, are selected from among (4E,6E)-7-{3-[2-(3,4-bis-hydroxymethylphenyl)-ethyl]phenyl}-3-ethylnona-4,6-dien-3-ol, (E)-6-[3-(3,4-bis-hydroxymethylbenzyloxy)phenyl]1,1,1-trifluoro-2-trifluoromethyloct-5-en-3-yn-2-ol, (3E,5E)-6-[3-(3,4-bis-hydroxymethylbenzyloxy)-phenyl]-1,1,1-trifluoro-2-trifluoromethylocta-3,5-dien-2-ol, (E)-6-{3-[2-(3,4-bis-hydroxymethylphenyl)ethyl]phenyl}-1,1,1-trifluoro-2-trifluoromethyloct-5-en-3-yn-2-ol, and (3E,5E)-6-{3-[2-(3,4-bis-hydroxymethylphenyl)-ethyl]phenyl-1,1,1-trifluoro-2-trifluoromethylocta-3,5-dien-2-ol, and the geometric isomers thereof and these compounds in which one or more of the hydroxyl functions are protected by a protective group —(C═O)—R, in which R is a linear or branched alkyl radical having from 1 to 6 carbon atoms, an aryl radical having from 6 to 10 carbon atoms, or an aralkyl radical having from 7 to 11 carbon atoms, the aryl radical or the aralkyl radical optionally being mono- or disubstituted by a hydroxy group, an alkoxy radical having from 1 to 3 carbon atoms, a halogen atom, a nitro function or by an amino function, and mixtures thereof.
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Inventors:
Jean-Michel Bernardon
Application Number:
JP2002591429A
Publication Date:
February 09, 2011
Filing Date:
May 22, 2002
Export Citation:
Assignee:
Galderma Research and Development
International Classes:
A61K8/30; C07C33/28; A61K8/00; A61K8/34; A61K8/67; A61K31/047; A61K31/085; A61P3/10; A61P3/14; A61P5/18; A61P9/10; A61P9/12; A61P11/06; A61P13/12; A61P17/00; A61P17/02; A61P17/06; A61P17/08; A61P17/14; A61P17/16; A61P19/00; A61P25/00; A61P27/02; A61P29/00; A61P31/12; A61P35/00; A61P35/02; A61P37/00; A61P37/08; A61Q5/00; A61Q5/12; A61Q7/00; A61Q19/00; A61Q19/08; C07C33/48; C07C43/23; C07C401/00
Foreign References:
| WO2000026167A1 |
Other References:
新実験化学講座 14 有機化合物の合成と反応 V,1978年 7月20日,2495-2516頁
Attorney, Agent or Firm:
Yasuhiko Murayama
Masatake Shiga
Takashi Watanabe
Shinya Mitsuhiro
Masatake Shiga
Takashi Watanabe
Shinya Mitsuhiro