PURPOSE: To obtain the subject composition, good in dispersibility in gastric juice, etc., in internal use, improved in absorbability, and effective in preventing formation of peroxylipids, etc., by blending vitamin E with a polyoxyethylene sorbitan ester and sorbitan dioleate in a specific proportion.
CONSTITUTION: A vitamin E composition obtained by blending a polyoxyethylene sorbitan ester with sorbitan dioleate which are active ingredients respectively at 9:1-6:4 blending ratio therein. For example, polyoxyethylene sorbitan monolaurate, polyoxyethylene sorbitan monopalmitate, etc., are cited as the polyoxyethylene sorbitan ester. The blending ratio of the vitamin E is 0.8-1.2 if the total blended amount of the polyoxyethylene sorbitan ester and sorbitan dioleate is 1. In preparing a pharmaceutical, polyhydric alcohols, such as polyethylene glycol, may be added in an amount of 5-10 times based on the total pharmaceutical.
OHASHI KOICHI
NEMOTO MASAMI
YAMAGUCHI HIROSHI
