Title:
The antibody to CD70
Document Type and Number:
Japanese Patent JP6261651
Kind Code:
B2
Abstract:
The present invention relates to antibodies and antigen binding fragments thereof which bind to the human CD70 protein with high affinity and display potent inhibition of tumour cell growth.
Inventors:
Karen Cirense
Peter Ulrikfts
Johannes Josep Wilhelms de Haard
Torsten Drayel
Michael joffun scotot sounders
Harald Wajant
Sophie Maria Elbile Gabriels
Mahan moss hill
Peter Ulrikfts
Johannes Josep Wilhelms de Haard
Torsten Drayel
Michael joffun scotot sounders
Harald Wajant
Sophie Maria Elbile Gabriels
Mahan moss hill
Application Number:
JP2016103443A
Publication Date:
January 17, 2018
Filing Date:
May 24, 2016
Export Citation:
Assignee:
Argen-X Bee Bie A
International Classes:
C07K16/28; C07K16/46; C12N15/09
Domestic Patent References:
| JP2008516970A | ||||
| JP2008538292A | ||||
| JP2009509510A | ||||
| JP2010513306A |
Foreign References:
| WO2009126934A1 |
Other References:
FRENCH, R.R. et al.,"ERADICATION OF LYMPHOMA BY CD8 T CELLS FOLLOWING ANTI-CD40 MONOCLONAL ANTIBODY THERAPY IS CRITICALLY DEPENDENT ON CD27 COSTIMULATION.",BLOOD,米国,AMERICAN SOCIETY OF HEMATOLOGY,2007年 6月 1日,Vol.109, No.11,P.4810-4815
MCEARCHERN, J.A. et al.,"PRECLINICAL CHARACTERIZATION OF SGN-70, A HUMANIZED ANTIBODY DIRECTED AGAINST CD70.",CLINICAL CANCER RESEARCH,米国,THE AMERICAN ASSOCIATION FOR CANCER RESEARCH,2008年12月 1日,Vol.14, No.23,P.7763-7772
ADAM, P.J. et al.,"CD70 (TNFSF7) IS EXPRESSED AT HIGH PREVALENCE IN RENAL CELL CARCINOMAS AND IS RAPIDLY INTERNALISED ON ANTIBODY BINDING.",BRITISH JOURNAL OF CANCER,HARCOURT PUBLISHERS,2006年 8月 7日,Vol.95, No.3,P.298-306
MCEARCHERN, J.A. et al.,"Engineered anti-CD70 antibody with multiple effector functions exhibits in vitro and in vivo antitumor activities.",BLOOD,2007年 2月 1日,Vol.109, No.3,P.1185-1192
MCEARCHERN, J.A. et al.,"PRECLINICAL CHARACTERIZATION OF SGN-70, A HUMANIZED ANTIBODY DIRECTED AGAINST CD70.",CLINICAL CANCER RESEARCH,米国,THE AMERICAN ASSOCIATION FOR CANCER RESEARCH,2008年12月 1日,Vol.14, No.23,P.7763-7772
ADAM, P.J. et al.,"CD70 (TNFSF7) IS EXPRESSED AT HIGH PREVALENCE IN RENAL CELL CARCINOMAS AND IS RAPIDLY INTERNALISED ON ANTIBODY BINDING.",BRITISH JOURNAL OF CANCER,HARCOURT PUBLISHERS,2006年 8月 7日,Vol.95, No.3,P.298-306
MCEARCHERN, J.A. et al.,"Engineered anti-CD70 antibody with multiple effector functions exhibits in vitro and in vivo antitumor activities.",BLOOD,2007年 2月 1日,Vol.109, No.3,P.1185-1192
Attorney, Agent or Firm:
Toru Ishikawa
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