Title:
A new molecular entity useful for the medical treatment of a degenerative disease and an inflammatory disease
Document Type and Number:
Japanese Patent JP5947372
Kind Code:
B2
Abstract:
A pyrazolopyridine compound according to Formula I, able to inhibit JAK is disclosed, as well as pharmaceutically acceptable salts, a solvate thereof, solvates of the pharmaceutically acceptable salts and biologically active metabolites thereof. The compound may be prepared as a pharmaceutical composition, and may be used for the treatment or prophylaxis of a variety of conditions in mammals including humans, and particularly, such conditions as may be associated with aberrant JAK activity, including by way of non-limiting example, allergy, inflammatory conditions, autoimmune diseases, proliferative diseases, transplant rejection, diseases involving impairment of cartilage turnover, congenital cartilage malformations, and/or diseases associated with hypersecretion of IL6.
Inventors:
Kufristel Jeanne Marie Menet
A la style james hodges
Fou David Butel
A la style james hodges
Fou David Butel
Application Number:
JP2014506865A
Publication Date:
July 06, 2016
Filing Date:
April 26, 2012
Export Citation:
Assignee:
Galapagos N.V.
International Classes:
C07D471/04; A61K31/437; A61K31/438; A61K31/444; A61K31/4545; A61K31/496; A61K31/5377; A61K31/541; A61K45/00; A61P1/04; A61P3/10; A61P11/06; A61P19/02; A61P29/00; A61P37/02; A61P37/06; A61P37/08; A61P43/00; C07D519/00
Domestic Patent References:
| JP2014512404A | ||||
| JP2010501633A |
Foreign References:
| WO2009017954A1 | ||||
| WO2010010190A1 | ||||
| WO2009155551A1 | ||||
| WO2010149769A1 | ||||
| WO2010010191A1 | ||||
| WO2010010186A1 |
Attorney, Agent or Firm:
Toru Ishikawa